These technologies could help put a stop to animal testing

Animal welfare groups have been campaigning for commitments like these for decades. But a lack of alternatives has made it difficult to put a stop to animal testing. Advances in medical science and biotechnology are changing that.

Animals have been used in scientific research for thousands of years. Animal experimentation has led to many important discoveries about how the brains and bodies of animals work. And because regulators require drugs to be first tested in research animals, it has played an important role in the creation of medicines and devices for both humans and other animals.

Today, countries like the UK and the US regulate animal research and require scientists to hold multiple licenses and adhere to rules on animal housing and care. Still, millions of animals are used annually in research. Plenty of scientists don’t want to take part in animal testing. And some question whether animal research is justifiable—especially considering that around 95% of treatments that look promising in animals don’t make it to market.

In recent decades, we’ve seen dramatic advances in technologies that offer new ways to model the human body and test the effects of potential therapies, without experimenting on humans or other animals.

Take “organs on chips,” for example. Researchers have been creating miniature versions of human organs inside tiny plastic cases. These systems are designed to contain the same mix of cells you’d find in a full-grown organ and receive a supply of nutrients that keeps them alive.

Today, multiple teams have created models of livers, intestines, hearts, kidneys and even the brain. And they are already being used in research. Heart chips have been sent into space to observe how they respond to low gravity. The FDA used lung chips to assess covid-19 vaccines. Gut chips are being used to study the effects of radiation.